Basic Information
VIS ID
TVIS10005581
Fusion event
HBV-LOC100507480 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1809
Orient
+
Integrated sequence
AAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAG| |CACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATT
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
36340121/36047920 (Hg38)
End
36340121/36047920 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC100507480
Nearest miRNA
hsa-mir-1233-1/Upstream/120997; hsa-mir-10393/Downstream/924901;
Nearest TSS
ENST00000557528/Upstream/1838; ENST00000561236/Downstream/204337;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/501606, chr15-CpG: 35/Downstream/531338
Upstream sequence
gagctagcgagaccatgaatccaccagaaggacaaaacaatgaacacatctcaacagcagaggggacaaactccagacgtgccaccttaagagctgtaac
Downstream sequence
actcaccgcgacggtccgcggcttcattcttgaagtcagtgagaccaagaacccaccaattctggacccaATATGTGTTCCTTCCATTGAGAAATGTTAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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