Basic Information
VIS ID
TVIS10005598
Fusion event
HBV-PANTR1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
50
Orient
-
Integrated sequence
CTCCACAACATTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTAT| |ATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACA
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
105457534/104841076 (Hg38)
End
105457534/104841076 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA2S
Target gene
PANTR1
Nearest miRNA
hsa-mir-1285-2/Upstream/2408710; hsa-mir-10b/Downstream/4300414;
Nearest TSS
ENST00000437798/Upstream/83357; ENST00000361360/Downstream/14435;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/181594, chr2-CpG: 210/Downstream/1639
Upstream sequence
TAGAAGTTTGCTATATTACACATGGGCATGTTATATGCAAATGTATTCAGTTGGGGtatgtatatattttgttatgttatgtacataaacatctaccctt
Downstream sequence
gtgcatatgtatatttacatcatgtataaatatgtgtagtatatTACCAAACTGTACTATACTTAAGGAGGAGGAGGAGCTTCCAAGGATTGCCATACAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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