Fusion event
HBV-RFTN1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
CCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTT| |CTAGGGGGAGCACCCACGTGTCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGCTATCGCTGGA
End
16376931/16335424 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-12127/Upstream/461575; hsa-let-7g/Downstream/597772;
Upstream sequence
tttgccacatgaggtgatatcaaggttctgaggtttagcaaatgaatggatgattttgagggccaccactcTCCACCCTCTACACTTGGTGGCTTggcct
Downstream sequence
tgcagccttaaaaaggaacgaatcacgtcctttgtggggacatggatggagctggaagctgttatccttagcaaactaacgcaggaacagaaaatcaaac
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).