Fusion event
HBV-chr6 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGAC
End
16972021/16971790 (Hg38)
Nearest miRNA
hsa-mir-3691/Upstream/830166; hsa-mir-10398/Downstream/1599994;
Upstream sequence
tgaaacactctttctgtagaatctgcaagtggataattggaccgccttgaggccttcgttggaaacgggatttcttcatgttactctagatagaagaatt
Downstream sequence
catacaaaaagatacatatttaacacattggactggttgtatggggagactggaataggaaatatggataaaagggattttaaaaagtaaagagggacct
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).