Fusion event
HBV-GTF2I integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
TTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAA| |GCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACT
End
74145259/74730921 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10525/Upstream/134895; hsa-mir-10399/Downstream/1184276;
Upstream sequence
CTGTTTTCCATTGATTTTGAATACATCAGAATCTATTGCCAGTTTTTGATTGTTTATTTAGTAGGCCATAAGAAAGATTCAAGTTTACTTCCATTTTGCA
Downstream sequence
gtctcaaactcctgacctcaagtgatcctcccgccttggcctcccaaagtgctggcattacaggcgtgagccacccttcccggccACTGCTTTTATCTTG
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).