Basic Information
VIS ID
TVIS10005629
Fusion event
HBV-chr7 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1793
Orient
+
Integrated sequence
CCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAA| |TTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
139782166/140082366 (Hg38)
End
139782166/140082366 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10399/Upstream/1038209; hsa-mir-11400/Downstream/2392161;
Nearest TSS
ENST00000635602/Upstream/18645; ENST00000495590/Downstream/9775;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/18921, chr7-CpG: 247/Downstream/93245
Nearby gene
KDM7A(+2380) ;
Junction sequence
ACAAGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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