Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005631
Fusion event
HBV-NRBP2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1840
Orient
-
Integrated sequence
TGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATC| |ATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGG
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
End
144914664/143832494 (Hg38)
Orient
-
Location type
Promoter
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-1204/Upstream/19452; hsa-mir-10400/Downstream/5262;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/2589, chr8-CpG: 30/Downstream/3348
Upstream sequence
tttaaattttaCTTTAGAGATACAACTTTTAGAATACAAAATATTTGTTTAAAAAAGCCTAAAAAAAGGCTTGATGATTTTTGAGTAACAAGGAATGCTG
Downstream sequence
tccctgggcaatggaatgtctccatataaaacctgattgcatgctccatctactgagatagggaaaaaccgccttagggctggaggtgggacctgcgggc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).