Basic Information
VIS ID
TVIS10005633
Fusion event
HBV-LINC00850 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1814
Orient
+
Integrated sequence
CTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCC
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
148975197/149846385 (Hg38)
End
148975197/149846385 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
LINC00850
Nearest miRNA
hsa-let-7f-2/Upstream/2561657; hsa-mir-105-1/Downstream/381619;
Nearest TSS
ENST00000429181/Upstream/20677; ENST00000493910/Downstream/34685;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/214362, chrX-CpG: 79/Downstream/91510
Upstream sequence
CAAACTTCACGTTATTTCACATTTTAAAATCTTTCATTTCTTCTACTATTTTCATACCTAAAAACCAGACAGTAATTTGCACTGTTCACTTATTTTTTAA
Downstream sequence
aaaccactaaatctggtccagtatctcactaacggggaactcacaggactcaccatatagtcctacccatgactacaacttattacagtgaaagggtacc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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