Basic Information
VIS ID
TVIS10005651
Fusion event
HBV-chr7 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1756
Orient
+
Integrated sequence
AGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAG| |GTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTC
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
145328669/145631576 (Hg38)
End
145328669/145631576 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10399/Upstream/2248776; hsa-mir-153-2/Downstream/1746441;
Nearest TSS
ENST00000635602/Upstream/795181; ENST00000637105/Downstream/49793;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/795416, chr7-CpG: 70/Downstream/484606
Upstream sequence
caggcatgttataatcccagtagaaataactaggcagtattttctggaattttaatagtattttaaattttaattatgagagtaaatgagcaaaaataac
Downstream sequence
gaattacaggcatgagccaccgcgcccagccAAAGTGATGGTTTTTGAATAGGGGTTAGCAAACTATAGCCCTAGCCTACTGCCCATTTTGTAATTAAAG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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