Basic Information
VIS ID
TVIS10005652
Fusion event
HBV-chr9 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2396
Orient
-
Integrated sequence
AGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGAC| |GAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATT
Host Sequence
Chromosome
chr9
Cytoband
p21.2
Reference genome
End
26327102/26327104 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-101-2/Upstream/4814919; hsa-let-7a-1/Downstream/2536522;
Upstream sequence
tagcacatcaattatattgcttttctaaaaaaaaatttagtgcttttcctagattttgcaatatacacttacaactaaatacattttcaaataactctat
Downstream sequence
GAGGACTAAAATGCTTCTGATTGGAGTGTAAAAGCAGGGGAAAATGAGATTCATATGTGCTATAATGTTGTCTAATGTTTCCACTCTAGTTCCTTAAGTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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