Basic Information
VIS ID
TVIS10005654
Fusion event
HBV-chr9 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1813
Orient
+
Integrated sequence
ACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACC
Host Sequence
Chromosome
chr9
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
30534444/30534446 (Hg38)
End
30534444/30534446 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA9C
Nearest miRNA
hsa-mir-101-2/Upstream/1645491; hsa-let-7a-1/Downstream/2574246;
Nearest TSS
ENST00000422679/Upstream/1864160; ENST00000541043/Downstream/40566;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/707708, chr9-CpG: 62/Downstream/719507
Upstream sequence
AGAATGGAATTTGGAATCTGGAAGAGGCTCATGATTTGTATTCATTGCAAATCCATTTTCCCACCCCAGATAAATGCTGAACAAATCTTAAAAGAATACG
Downstream sequence
TTTTCCGTTAGCCTTTTCCCGCCACATTTCTGAATAAGTAAAATGCTAATTTTCTCTCGCTTTACAATTTGACGTTTTGTTGTTGCAGTCAGCATTGCAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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