Basic Information
VIS ID
TVIS10005661
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2774
Orient
-
Integrated sequence
GCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATT| |CTATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGA
Host Sequence
Chromosome
chr5
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
21346833/21346724 (Hg38)
End
21346833/21346724 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/4190732; hsa-mir-103a-1/Downstream/10589378;
Nearest TSS
ENST00000502646/Upstream/5349; ENST00000606105/Downstream/223031;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1040897, chr5-CpG: 38/Downstream/112636
Upstream sequence
gcggaggaggcggagctggaaggtgaaggggcaggacgggTGCCCGGGTCCCCAGTCCCTCCGCCACGTGGGAAGCGCGGTCCTGGGCGTCTGTGCCCGC
Downstream sequence
ttttgagagatgttgatatttatttatattttgattacattgagatctaagagtgtgcttgatattatttcattttttaaaatttatccagacttgcttt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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