Basic Information
VIS ID
TVIS10005664
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2775
Orient
-
Integrated sequence
CCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTC| |TATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGAC
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
69581237/70285410 (Hg38)
End
69581237/70285410 (Hg38)
Orient
-
Location type
Intronic
Target gene
GUSBP3 ; SMA4
Nearest miRNA
hsa-mir-10397/Upstream/10581707; hsa-mir-103a-1/Downstream/1884057;
Nearest TSS
ENST00000502646/Upstream/214746; ENST00000602697/Downstream/164226;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/235416, chr5-CpG: 39/Downstream/129719
Upstream sequence
ctgggccggggacccgggaggggtcgggacggggcggggtccgcgcggaggaggcggagctggaaggtgaaggggcaggacgggTGCCCGGGTCCCCAGT
Downstream sequence
ctacacaaatagatgaaaattaaacaactttctcctgaataacttctgtgtgaaaatcaaaattaagggagaaattttaagaaagtgaaattaatgaaaa
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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