Basic Information
VIS ID
TVIS10005667
Fusion event
HBV-LOC653080 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2775
Orient
-
Integrated sequence
CCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTC| |TATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGAC
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
70020526/70724699 (Hg38)
End
70020526/70724699 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC653080
Nearest miRNA
hsa-mir-10397/Upstream/11020996; hsa-mir-103a-1/Downstream/1444768;
Nearest TSS
ENST00000502646/Upstream/275063; ENST00000511162/Downstream/175966;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/309218, chr5-CpG: 61/Downstream/175916
Upstream sequence
TTGTATTTCACTACATCAATTGATAGTCTATTTTACTGCAAGCCATCGTATGTCCTTTTTGAGAACAGTTTAAATTGTAACCACAAAATGAAAGGAATAA
Downstream sequence
gttgagagatgttggtatttatttatattttgattacattgagatctaagagtgtgcttgatatgatttcattttttaaaatttatccagacttgcttta
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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