Basic Information
VIS ID
TVIS10005669
Fusion event
HBV-GUSBP2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2775
Orient
-
Integrated sequence
CCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTC| |TATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGAC
Host Sequence
Chromosome
chr6
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
26919478/26951699 (Hg38)
End
26919478/26951699 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA6C
Target gene
GUSBP2
Nearest miRNA
hsa-mir-3691/Upstream/8379819; hsa-mir-10398/Downstream/195927;
Nearest TSS
ENST00000381078/Upstream/265458; ENST00000607607/Downstream/5293;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/55702, chr6-CpG: 43/Downstream/68120
Upstream sequence
TGCTCTTACAATTGCTTCCATTTGAATAAGTTACATGGTCACCCTACATATGGATGATTCTCTAGAATTCGAGCAGCCAGAATAATTTACTAAttgtagc
Downstream sequence
ctacacaaatagatgaaaattaaacaactttctcctgaataacttctgtgtgaaaatcaaaattaagggagaaattttaagaaagtgaaattaatgaaaa
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate