Basic Information
VIS ID
TVIS10005681
Fusion event
HBV-GLIS2-AS1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
3215
Orient
+
Integrated sequence
CAGCGCCTCCTCCTGCCTCCACCAATCGGCAGTCAGGAAGACAGCCTACTCCCATCTCTCCACCTCTAAGAGACAGTCATCCTCAGGCCATGCAGTGGAA| |
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
4375438/4325437 (Hg38)
End
4375438/4325437 (Hg38)
Orient
+
Location type
Intronic
Target gene
GLIS2-AS1
Nearest miRNA
hsa-mir-1225/Upstream/839968; hsa-mir-11401/Downstream/345881;
Nearest TSS
ENST00000527434/Upstream/10676; ENST00000433375/Downstream/2903;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/8456, chr16-CpG: 64/Downstream/2070
Junction sequence
TTGTGGTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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