Basic Information
VIS ID
TVIS10005685
Fusion event
HBV-chr7 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1786
Orient
+
Integrated sequence
CGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAG| |GCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTG
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
71198439/71733454 (Hg38)
End
71198439/71733454 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7J
Nearest miRNA
hsa-mir-1183/Upstream/425684; hsa-mir-10399/Downstream/964449;
Nearest TSS
ENST00000635602/Upstream/397905; ENST00000434423/Downstream/77041;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/600058, chr7-CpG: 187/Downstream/602318
Upstream sequence
AGATGGGGAGGATAAGGAGGGGAGGGGGAGGAGAGCCTGCATATAAAAAAAGACCCAAAGAGAAGACtttttttttgagacagagtatcgttctgttgcc
Downstream sequence
GCCCCCTGCTGGCGCCTGGCCTTGATTCCGCTGCTTCCTTTCCCCTGAAATGAAGGAAAGCAGGAGGGTTGTGAGGCTTCATTGATTTCTCCCCGGCGGA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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