SDCCAG8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005700
Fusion event
HBV-SDCCAG8 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1928
Orient
-
Integrated sequence
CTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTG| |GAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGA
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh37/hg19
Start
243556275/243392973 (Hg38)
End
243556275/243392973 (Hg38)
Orient
-
Location type
Intron
Target gene
SDCCAG8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-101-1/Upstream/46718; hsa-mir-3124/Downstream/3808994;
Nearest TSS
ENST00000473358/Upstream/54220; ENST00000463042/Downstream/25044;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/137500, chr1-CpG: 48/Downstream/81364
Upstream sequence
AAACTGTTAACGGAGAATTAACTTCTTTGGCATGCTTTCATACTTATCTTCCAAATTAAAGAAAATGAAATGGGCAGAAACAGAGTGTAGATTACCTCCT
Downstream sequence
TTTTGTCAAAAATGGTGGGAATTTGAAAATTAATAATAAAAAAGGGAACAGATGCAGTAACATGCCAGAGGGAGATTAATGTGGAGAGTAAAATCTGTGA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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