Basic Information
VIS ID
TVIS10005711
Fusion event
HBV-LOC100507513 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1810
Orient
+
Integrated sequence
AAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGC| |ACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTG
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
21403736/20935577 (Hg38)
End
21403736/20935577 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC100507513
Nearest miRNA
hsa-mir-1185-1/Downstream/87737;
Nearest TSS
ENST00000550708/Upstream/6997; ENST00000304625/Downstream/678;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/211876, chr14-CpG: 27/Downstream/35842
Upstream sequence
GGCCCAACACTTAGTGTTCGCAGTTCTCCCCTCCTGCCATTTCTACACTTATTCTTCGTGTACTCATGGCAACAAGTGTTCTCACATCCTTCTTCCACCT
Downstream sequence
CCTTGTCAATAACGGAGATGGCTACCACCCTCTCAACCCTTTATGGGATTATCCTATGTACAAGGTTATTTCCAAACCCCAAAGTGATTCTTGCTCCTTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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