Fusion event
HBV-chr14 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAA
End
27778537/27309331 (Hg38)
Nearest miRNA
hsa-mir-208a/Upstream/400606; hsa-mir-1185-1/Downstream/323874;
Upstream sequence
ttctggtggaagacttttatttggttctgtgaatacttattttgtttcctatgtatttctagcagtcatcattcattccatttatctagaattcctaagc
Downstream sequence
tacctgtattgggacagcaggaattaatggagcacaccagctttctatctttaaactaactttttgaattttaggcttccttatactttaagtgtgttga
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).