Basic Information
VIS ID
TVIS10005717
Fusion event
HBV-chr15 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1829
Orient
-
Integrated sequence
CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACC| |TCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGG
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
46642530/46350332 (Hg38)
End
46642530/46350332 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/917203; hsa-mir-11181/Downstream/2818738;
Nearest TSS
ENST00000557528/Upstream/645137; ENST00000559148/Downstream/342956;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/645126, chr15-CpG: 96/Downstream/833840
Nearby gene
MTND5P40(-8633) ;
Upstream sequence
TTACTTCAAACATGATGAAAGTGTCTTTAAATTTCAGATGATATATAAAACAAAACCAGATACAGTATGGAATTCAGAGCTGTGAAGGAGTTATGAAGTG
Downstream sequence
TATCTGAAGTTTATAATTTAAATTATCAAGTATTTGTAAAAAATTATCAAGTATTTGTAAAGCTACTGCATTTAAAATATGTTAAATGTTTTTGTAGAAC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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