Basic Information
VIS ID
TVIS10005729
Fusion event
HBV-SSUH2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2161
Orient
+
Integrated sequence
ACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGC| |TATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTGAGTATTTGGTGT
Host Sequence
Chromosome
chr3
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
8699780/8658094 (Hg38)
End
8699780/8658094 (Hg38)
Orient
+
Location type
Intronic
Target gene
SSUH2
Nearest miRNA
hsa-mir-4790/Upstream/3407839; hsa-let-7g/Downstream/1622257;
Nearest TSS
ENST00000440867/Upstream/6020; ENST00000397368/Downstream/872;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/156201, chr3-CpG: 184/Downstream/109181
Upstream sequence
gagacgggttttcaccatgttggtcaggctggccttgaattccagaccttgtgatccacccacctcggccaccatgcccggctaatttgtatttttagta
Downstream sequence
gcaggtcacttaacctctctgaccctcagcttctacatcagaaaactggggatgaccctcatggagatatttattacaggctaagagatgacgacatgtg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate