Basic Information
VIS ID
TVIS10005738
Fusion event
HBV-CCSER1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1820
Orient
+
Integrated sequence
GTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAA
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
91797559/90876408 (Hg38)
End
91797559/90876408 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA4E
Target gene
CCSER1
miRNAs that regulate target gene
hsa-mir-544a
Nearest miRNA
hsa-mir-12113/Upstream/3575825; hsa-mir-1243/Downstream/8120979;
Nearest TSS
ENST00000502981/Upstream/60595; ENST00000505511/Downstream/236382;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/37292, chr4-CpG: 26/Downstream/1306058
Upstream sequence
gttgcccaggctggagttcagtggcgcaatctcggctcactgcaacctccacctcccaggttcaagcaattctcctgcctcagcctactgagtagctggg
Downstream sequence
GTGCTGGCAACACAACAGAGATGGAAGCAATCATGTGTGAAAGGTTAATAACATGATATTTTAAGATTAAAAAGATGAAACTAAGCTTTTCCGTATTTGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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