Basic Information
VIS ID
TVIS10005748
Fusion event
HBV-chr8 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2193
Orient
-
Integrated sequence
TGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAG| |ACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCT
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
End
91164701/90152473 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/9911000; hsa-mir-10400/Downstream/1053012;
Upstream sequence
CTACTCAGCTTCCCTAGTTTTTTTTTTTTTTTAGCTGACTTTGCTTGAGCTATTTTTCAATGAGTCACCTCTTCCTATGAAATTGAAAACTGGTCACTTT
Downstream sequence
tttttattgtagctgttcttgtgggtgtgtagtggtagctcactggtattaatttgcgcttactggtattaatttgcgctcactgaaaattatgagttga
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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