Fusion event
HBV-chr8 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
TGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAG| |ACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCT
End
91164701/90152473 (Hg38)
Nearest miRNA
hsa-mir-12123/Upstream/9911000; hsa-mir-10400/Downstream/1053012;
Upstream sequence
CTACTCAGCTTCCCTAGTTTTTTTTTTTTTTTAGCTGACTTTGCTTGAGCTATTTTTCAATGAGTCACCTCTTCCTATGAAATTGAAAACTGGTCACTTT
Downstream sequence
tttttattgtagctgttcttgtgggtgtgtagtggtagctcactggtattaatttgcgcttactggtattaatttgcgctcactgaaaattatgagttga
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).