Basic Information
VIS ID
TVIS10005749
Fusion event
HBV-LOC105375760 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1804
Orient
+
Integrated sequence
ACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
132256032/131243785 (Hg38)
End
132256032/131243785 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375760
Nearest miRNA
hsa-mir-1204/Upstream/1235332; hsa-mir-10400/Downstream/1802696;
Nearest TSS
ENST00000518652/Upstream/98904; ENST00000519005/Downstream/64760;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/201282, chr8-CpG: 92/Downstream/660218
Upstream sequence
AGTTTTTTTTTTTTTTTAGCTGACTTTGCTTGAGCTATTTTTCAATGAGTCACCTCTTCCTATGAAATTGAAAACTGGTCACTTTCAGAAGCTATTCTGC
Downstream sequence
tggaatcctgtctgtgccattactttagaagtataaaatgaagataataattattatataagagggccgttgaaagcattaaatgagataacgtgtgcaa
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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