Basic Information
VIS ID
TVIS10005754
Fusion event
HBV-LINC01201 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1827
Orient
-
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTT
Host Sequence
Chromosome
chrX
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
130159796/131025822 (Hg38)
End
130159796/131025822 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC01201
Nearest miRNA
hsa-let-7f-2/Upstream/9654769; hsa-mir-105-1/Downstream/3143556;
Nearest TSS
ENST00000429181/Upstream/122505; ENST00000423277/Downstream/14024;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/122638, chrX-CpG: 60/Downstream/32335
Upstream sequence
tggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
TTGGAGTGTTTGGAGGCAGATTAGTGTGGATTCTACAGAGCTGGCTGCTCTCTTGGAGCCCACTCCCAATTCCTGAACTCCTGCTCTCTTAGGTTTACAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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