hsa-mir-4753-3p _LIHC.png
DHRS3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005755
Fusion event
HBV-DHRS3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1796
Orient
+
Integrated sequence
TGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG| |GTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTG
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
GRCh37/hg19
Start
12658164/12598151 (Hg38)
End
12658164/12598151 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA1A
Target gene
DHRS3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-92a-3p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-4719
Nearest miRNA
hsa-mir-12136/Upstream/19128; hsa-mir-101-1/Downstream/4260798;
Nearest TSS
ENST00000473358/Upstream/1843; ENST00000376221/Downstream/18545;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1916, chr1-CpG: 124/Downstream/18827
Upstream sequence
AGAACGTATCACACATCCCCAGCAGACAGGTGACACCTGCCAAACTAAAAGTTGCCTGCACATCCAGTCTCTACATGTGCAGGGGCAGTGGACATGGCAG
Downstream sequence
CGTATGAGCTGTAGGGGAAAGAGGAATAATAACAACAGGTaacctgggcaacatggtgaaagcctgtctccactaaaaatacaaaagttagccaggcatg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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