Basic Information
VIS ID
TVIS10005757
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1810
Orient
+
Integrated sequence
AAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGC| |ACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTG
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
196118082/196148952 (Hg38)
End
196118082/196148952 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/3012369; hsa-mir-1182/Downstream/433461;
Nearest TSS
ENST00000473358/Upstream/87879; ENST00000496761/Downstream/279255;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3026858, chr1-CpG: 24/Downstream/459626
Upstream sequence
aataagaaataatataattctatttgtatttttgattgtcatttattattattttttaatttaaCAGAAGAGATATTTCCTTCTCCTCTACCCACAGGGT
Downstream sequence
CAGTTAGCATAACAGTCGCAGAGCAAGCATTCAGGAGAATAACAAGCTCAATAACAAGCTGAAAGAACATTTTCATTAATTTGGTCATTCCTTCTCTTGC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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