Basic Information
VIS ID
TVIS10005758
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
3072
Orient
+
Integrated sequence
TTGGGACTTCAACCCCAACAAGGATCACTGGCCAGAGGCAAATCAGGTAGGAGCGGGAGCATTCGGGCCAGGGTTCACCCCACCACACGGCGGTCTTTTG| |GGGTGGAGCCCTCAGGCTCAGGGCATATTGACAACAGTGCCAGCAGCGCCTCCTCCTGCCTCCACCAATCGGCAGTCAGGAAGACAGCCTACTCCCATCT
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
End
196118060/196148930 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-101-1/Upstream/3012347; hsa-mir-1182/Downstream/433483;
Upstream sequence
GTTGGCACAATTATCTTTCaaaaataagaaataatataattctatttgtatttttgattgtcatttattattattttttaatttaaCAGAAGAGATATTT
Downstream sequence
CCTTCTCCTCTACCCACAGGGTCAGTTAGCATAACAGTCGCAGAGCAAGCATTCAGGAGAATAACAAGCTCAATAACAAGCTGAAAGAACATTTTCATTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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