MARK1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005761
Fusion event
HBV-MARK1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2131
Orient
-
Integrated sequence
TCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAA| |GACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTG
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
220722090/220548748 (Hg38)
End
220722090/220548748 (Hg38)
Orient
-
Location type
Intron
Target gene
MARK1
miRNAs that regulate target gene
hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-1283
Nearest miRNA
hsa-mir-101-1/Upstream/348129; hsa-mir-1182/Downstream/3708292;
Nearest TSS
ENST00000473358/Upstream/19898; ENST00000294889/Downstream/141097;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/19742, chr1-CpG: 85/Downstream/141417
Upstream sequence
gaattgcttgaacctgggaggcagagactgtggtgagccggaggctgcggtgagccgagattgtgccactgcactccagcctgggtggacagtaagactc
Downstream sequence
ccatctcagaaaaaaaatataataataataattaataaataaaGAACAAACACCTATTGTAATTTCTGGCATGAGTTTGCTGTAACGTTTTTGTTCTTGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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