Basic Information
VIS ID
TVIS10005768
Fusion event
HBV-NDUFC2-KCTD14 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1791
Orient
+
Integrated sequence
GACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATA| |AATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGG
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
End
77764225/78053179 (Hg38)
Orient
+
Location type
Intron
Target gene
Nearest miRNA
hsa-mir-10392/Upstream/2717993; hsa-let-7a-2/Downstream/1348843;
Upstream sequence
taattttttttgtgtgtgtatttttagtagagatggggtttcaccatgttgaccgggctggtctcgaactcctgacctcaagtgatccacctgtgctggg
Downstream sequence
tgtgagccactgcacctggccTCGTtaccttattttcttcctagtacaagtcacaatgtgatgttaaccatattgatctgtgcattgttggtcattgctc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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