Basic Information
VIS ID
TVIS10005769
Fusion event
HBV-NDUFC2-KCTD14 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1801
Orient
+
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |TTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
77764251/78053205 (Hg38)
End
77764251/78053205 (Hg38)
Orient
-
Location type
Intron
Target gene
NDUFC2-KCTD14
miRNAs that regulate target gene
hsa-mir-3149 ; hsa-mir-7152-5p ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-4777-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-376a-5p ; hsa-mir-4326 ; hsa-mir-567 ; hsa-mir-643 ; hsa-mir-1266-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-144-3p ; hsa-mir-1227-3p ; hsa-mir-5189-3p ; hsa-mir-6889-3p ; hsa-mir-2115-3p ; hsa-mir-551b-5p
Nearest miRNA
hsa-mir-10392/Upstream/2718019; hsa-let-7a-2/Downstream/1348817;
Nearest TSS
ENST00000527297/Upstream/7014; ENST00000281030/Downstream/10656;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/30028, chr11-CpG: 64/Downstream/26227
Junction sequence
GG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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