Basic Information
VIS ID
TVIS10005775
Fusion event
HBV-chr12 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1312
Orient
+
Integrated sequence
TTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTG| |GAGCAAAACTTATCGGGACTGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTTCCCATGGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGG
Host Sequence
Chromosome
chr12
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
61786293/61392512 (Hg38)
End
61786293/61392512 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1228/Upstream/3567820; hsa-let-7i/Downstream/867847;
Nearest TSS
ENST00000382841/Upstream/1299648; ENST00000546718/Downstream/434721;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1795786, chr12-CpG: 117/Downstream/798475
Upstream sequence
CTGAGGAATTCAGGGCCTTGAGTCATGTCAGATCAAATTATGGATCAGAAGCACACAAATATTGTGCAGAGGAATTTCAAACCAATTTCTTCTATAGAAT
Downstream sequence
ACAGTGAAGTTAATTTTAAATATATGTCTTAATTATAAGAGTTACTTCTTTTAAATAAATGTCTAGGTAATTCTGCACATTTGCATGATTCTGAATTTCA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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