Basic Information
VIS ID
TVIS10005782
Fusion event
HBV-chr14 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1820
Orient
+
Integrated sequence
GTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAA
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
69275295/68808578 (Hg38)
End
69275295/68808578 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA14C
Nearest miRNA
hsa-mir-208a/Upstream/1366648; hsa-mir-1185-1/Downstream/3708242;
Nearest TSS
ENST00000550708/Upstream/12325; ENST00000553944/Downstream/70444;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/12395, chr14-CpG: 76/Downstream/7751
Upstream sequence
CCAAGAGTCTTTAATACACCCCACAATTACCAGCCTCTTCTAGCATTCCCCCTGCACCCTCAAAATGACCACTGGCCAAGGGCTGTGATAGTGGGAAAAA
Downstream sequence
AGGACTTTCCACTGGAAAACTGCCTCTGTCTCCCCAGCAGACACCTCTGGATGCCCAGGTCAACTTCAGCCACTGAGTCAGAATTGAAGGAAACCCAGAC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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