Basic Information
VIS ID
TVIS10005785
Fusion event
HBV-GOLGA6L22 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1807
Orient
+
Integrated sequence
TCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr15
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
23574259/23329111 (Hg38)
End
23574259/23329111 (Hg38)
Orient
-
Location type
Intronic
Target gene
GOLGA6L22
Nearest miRNA
hsa-mir-1268a/Upstream/131191; hsa-mir-10393/Downstream/232951;
Nearest TSS
ENST00000557528/Upstream/192289; ENST00000562295/Downstream/25637;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/25297, chr15-CpG: 102/Downstream/357301
Upstream sequence
GATTGACCCCCTACCCTCGCCCCACaaccacagaaccgtggcgctggaagggaccccaggaattaaaagtcccaggtggcaggccagagagaagacatga
Downstream sequence
gttgcctgaggctaccccatgagtcagtggcacagccagcactagagcttccgtgtgcACACATGAAAACATGTATGAGCCTCTCCCCACACTCACCTGG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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