Basic Information
VIS ID
TVIS10005792
Fusion event
HBV-chr18 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1846
Orient
-
Integrated sequence
AGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCA| |TGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTAC
Host Sequence
Chromosome
chr18
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
40709049/43129084 (Hg38)
End
40709049/43129084 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/3452305; hsa-mir-122/Downstream/1840998;
Nearest TSS
ENST00000575820/Upstream/13393; ENST00000591940/Downstream/143067;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/3287219, chr18-CpG: 180/Downstream/1549934
Upstream sequence
TAGACTATAAAAATATAGCTGGTTGTTTTTAGTCTAAAATATGACACAAATGTATGGTATATGGTTTTGCTATTAATATTTTGAAAAGACTATAAtgtat
Downstream sequence
tgaaataaatttggtttatttgtaatttcttcccatttgttttagatttactgtgtgcagcaatagagaacaatcttcctcaaaaataaatatttaaatg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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