Basic Information
VIS ID
TVIS10005794
Fusion event
HBV-LINC01924 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1827
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTT
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
62003083/64335848 (Hg38)
End
62003083/64335848 (Hg38)
Orient
-
Location type
Intron
Target gene
LINC01924
Nearest miRNA
hsa-mir-1-2/Upstream/5884690; hsa-mir-5011/Downstream/2745736;
Nearest TSS
ENST00000575820/Upstream/75793; ENST00000578545/Downstream/789862;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/332827, chr18-CpG: 88/Downstream/1414752
Upstream sequence
TCCTTGTGAAGGCTAAAAATAAACAGGATGGAGTTAGGCCAGACACCATCATAGTAAGACTTTTAGAGACAGACATTTCATTCCAAAAATTGAGTCTTGA
Downstream sequence
ATATAAAACTCTCTTTTTGGTTATCTAAGCACTAAGTCCACATACACAGGAGTCTATGAGTCTAATGTTTCCTTCATGACTCTTATTCAAAATTAGGGCA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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