Fusion event
HBV-chr2 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
ACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACC
End
227132279/226267563 (Hg38)
Nearest miRNA
hsa-mir-10b/Upstream/1257023; hsa-mir-1244-1/Downstream/391147;
Upstream sequence
TCCACCTTTGAGAAGCTGAGGTAGTCTGAGATTGACAACTAtctggcttctcatgagctcttagcacaggcaaagattctattttcctgaccctctggaa
Downstream sequence
gttaagcttggccatgaaactttactctggccacggaactttcctctgggcactgacataggggcagaagtgattcatgtcattcctgggtggaagcaca
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).