Basic Information
VIS ID
TVIS10005803
Fusion event
HBV-chr21 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1810
Orient
+
Integrated sequence
AAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGC| |ACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTG
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
21925827/20553514 (Hg38)
End
21925827/20553514 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/1867350; hsa-mir-155/Downstream/2525770;
Nearest TSS
ENST00000624081/Upstream/294694; ENST00000486367/Downstream/249549;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/2307957, chr21-CpG: 89/Downstream/443591
Upstream sequence
AAAGTTAAGAATACTTCTATCTTTATAAAGAAGTAGATACTATTCCAATCTCATTAGGAAAAATAATCTGCACGCCTAGAGAAGCCTTAATCAGCATGTA
Downstream sequence
TTGAGCATCAACTAAGTGCAACATTTCTGTTAAGACACTGTTAAGGATCAACGAAGAAATAAAACAGTATCTCCAAGAAAGTtgactctatactttccct
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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