Fusion event
HBV-chr3 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTA| |GACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATG
End
44454525/44413033 (Hg38)
Nearest miRNA
hsa-mir-12127/Upstream/298723; hsa-let-7g/Downstream/448855;
Upstream sequence
ccacactttgttttggtaggatataccttctacaagtttcatgagaaaatgtccaaaagagataaaattttgaatccttgcatgtcacacatatctttat
Downstream sequence
acaccagccctggagaggggcctcccttctaaccttccttttttttttttttttgagatggagtctcgctgtgtcgcccaggctggagtgcaatggcatg
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).