Basic Information
VIS ID
TVIS10005807
Fusion event
HBV-chr3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2348
Orient
+
Integrated sequence
GAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTA| |GACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATG
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
End
44454525/44413033 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/298723; hsa-let-7g/Downstream/448855;
Nearby gene
TCAIM(-3585) ; C3orf86(+5394) ;
Upstream sequence
ccacactttgttttggtaggatataccttctacaagtttcatgagaaaatgtccaaaagagataaaattttgaatccttgcatgtcacacatatctttat
Downstream sequence
acaccagccctggagaggggcctcccttctaaccttccttttttttttttttttgagatggagtctcgctgtgtcgcccaggctggagtgcaatggcatg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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