VISDB Viral Integration Site DataBase

VIS ID

TVIS10005814

Fusion event

HBV-TMEM154 integration

Validated

No

Detection method

PCR and Ultra-deep sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Start

1821

Orient

+

Integrated sequence

TTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAA

Chromosome

chr4

Cytoband

q31.3

Reference genome

Start

End

153598509/152677357 (Hg38)

Orient

+

Location type

Intron

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-16-5p ; hsa-mir-3922-5p ; hsa-mir-548e-5p ; hsa-mir-5096 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-197-3p ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-6890-5p ; hsa-mir-548c-3p ; hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6767-3p ; hsa-mir-5092 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-6131 ; hsa-mir-3934-3p ; hsa-mir-3670 ; hsa-mir-3663-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4740-3p ; hsa-mir-6854-5p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-4537 ; hsa-mir-3117-5p ; hsa-mir-1200 ; hsa-mir-1281 ; hsa-mir-1297 ; hsa-mir-1915-3p ; hsa-mir-1976 ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-3672 ; hsa-mir-4279 ; hsa-mir-4293 ; hsa-mir-4324 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4465 ; hsa-mir-4722-3p ; hsa-mir-4726-3p ; hsa-mir-4768-3p ; hsa-mir-4786-5p ; hsa-mir-544b ; hsa-mir-548as-3p ; hsa-mir-5571-5p ; hsa-mir-5585-3p ; hsa-mir-570-3p ; hsa-mir-6513-3p ; hsa-mir-660-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6764-5p ; hsa-mir-6771-3p ; hsa-mir-6778-3p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6840-3p ; hsa-mir-6849-3p ; hsa-mir-6864-3p ; hsa-mir-6869-5p ; hsa-mir-769-5p ; hsa-mir-8062

Nearest miRNA

hsa-mir-12113/Upstream/140841; hsa-mir-1305/Downstream/6451445;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/140666, chr4-CpG: 71/Downstream/102030

Upstream sequence

TCTGTAACCAAATTAGCATGTTTGAGACAATATATTAAATTCAAAAATTTAAAACTCTTTTGTAACATATGAATTGTTTTCATTGCCTAGGGGAATAAGT

Downstream sequence

AGATACATCTCAGAGTATACTCACAAACAGTGTCAGGCCCTTCAGTAGGTTGGATTCATCTAACAAACATCCCCAGGTATTTTTTGAAGAATTCAAGGAA