Basic Information
VIS ID
TVIS10005817
Fusion event
HBV-chr4 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1784
Orient
+
Integrated sequence
AACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGT| |AGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCT
Host Sequence
Chromosome
chr4
Cytoband
q34.1
Reference genome
End
174958509/174037358 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/769125; hsa-mir-1305/Downstream/386437;
Upstream sequence
ATTTGGGGATAGAAAAAGGTAAAGCAGTGTTTTTGTAGAAATTTTTCCATAGAACACAGTTACGGTTGTTGCTTTTCATAAAGGAAGAATAAAACAGATA
Downstream sequence
GTATTTCTGAACAATAATCTTGAAAGGCAGCAATAAAATACATCAGGATCCTTTGAGCTGGCCAAGCTTTCATCCAAATGGCTTATTACAAAGAGCTGGC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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