Fusion event
HBV-chr4 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
AACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGT| |AGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCT
End
174958509/174037358 (Hg38)
Nearest miRNA
hsa-mir-12113/Upstream/769125; hsa-mir-1305/Downstream/386437;
Upstream sequence
ATTTGGGGATAGAAAAAGGTAAAGCAGTGTTTTTGTAGAAATTTTTCCATAGAACACAGTTACGGTTGTTGCTTTTCATAAAGGAAGAATAAAACAGATA
Downstream sequence
GTATTTCTGAACAATAATCTTGAAAGGCAGCAATAAAATACATCAGGATCCTTTGAGCTGGCCAAGCTTTCATCCAAATGGCTTATTACAAAGAGCTGGC
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).