Basic Information
VIS ID
TVIS10005818
Fusion event
HBV-chr6 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1758
Orient
+
Integrated sequence
AGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGT| |TAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCT
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
68214409/67504516 (Hg38)
End
68214409/67504516 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/10114304; hsa-mir-10524/Downstream/3872444;
Nearest TSS
ENST00000381078/Upstream/1797291; ENST00000449928/Downstream/384823;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1409578, chr6-CpG: 37/Downstream/1130324
Upstream sequence
ACCCGGTAGTTAACAGGCATCTGGCATAATTCTCCATGTCTGTCCACAAGGCCCAGAGGAAGGACAGAAATAGGAATCCCCAGTGGGGCCAGAGAAGCTT
Downstream sequence
agtgcaaggtgaagcagaacgtgctcatgtagaagctgcagcaagtGCTGATCAAGTAGTGTAAAGGGAATTGAAAGGATGTGGGTAGAACTCTGGCAGC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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