KIF27 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005827
Fusion event
HBV-KIF27 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1826
Orient
+
Integrated sequence
GGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
Host Sequence
Chromosome
chr9
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
86457005/83842090 (Hg38)
End
86457005/83842090 (Hg38)
Orient
+
Location type
Intron
Target gene
KIF27
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3606-5p ; hsa-mir-6073 ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-27b-5p ; hsa-mir-196b-5p ; hsa-mir-196a-5p ; hsa-mir-583
Nearest miRNA
hsa-mir-101-2/Upstream/13032006; hsa-let-7a-1/Downstream/127658;
Nearest TSS
ENST00000422679/Upstream/5038; ENST00000615485/Downstream/5473;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/23911, chr9-CpG: 101/Downstream/78737
Upstream sequence
ACAGCAAGTAGGCAGGTATGTGGGAAACCGGATTTAAGTTCAGATGTTCCCATGGGAAAATGAATAAATTAAAGAGCATACATTTTCAGTTTTTGTAATA
Downstream sequence
GACAACGATTTTTGTTTACAGAGACAAATAGAAGTATCTAATCCTAAATAACCCAGTCAATTGGTAAAGGCTACACTACAAAGCTGGCATGACTTCACCA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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