Basic Information
VIS ID
TVIS10005836
Fusion event
HBV-chr4 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2761
Orient
-
Integrated sequence
TTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTG| |GAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTC
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
33650690/33649068 (Hg38)
End
33650690/33649068 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/4829400; hsa-mir-1243/Downstream/2777298;
Nearest TSS
ENST00000502981/Upstream/215558; ENST00000504795/Downstream/201523;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2925848, chr4-CpG: 100/Downstream/2594941
Upstream sequence
gaaatagtaacaaccttagaaattatccagtcTTAGGATGGCAATCTTTGAAAAATTTAAGTTGAAAAATGCAATGCTGTCTAAAGCTGATTGGAACTTG
Downstream sequence
TTAGATTTGGATATAGATAATGCCCTGAGGGAGATATACTGTAGAACAgtttctcaattgtgacactattgacattttgggctggataagtctttgttgt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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