Basic Information
VIS ID
TVIS10005840
Fusion event
HBV-FYB2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1495
Orient
+
Integrated sequence
AACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGGCTCTACCGTCCCCTTC| |TTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACC
Host Sequence
Chromosome
chr1
Cytoband
p32.2
Reference genome
GRCh37/hg19
Start
57257052/56791379 (Hg38)
End
57257052/56791379 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA1B
Target gene
FYB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1565656; hsa-mir-101-1/Downstream/2941848;
Nearest TSS
ENST00000473358/Upstream/29366; ENST00000361249/Downstream/27992;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/145815, chr1-CpG: 222/Downstream/630912
Upstream sequence
ggatcttgctctgttgcccaggctggagtgaagtggtacaattttggctcactacaacctctgcctcccaggttcaagcaattcttgtgtctcagcttcc
Downstream sequence
cgagtagctgggattacaggcacaggccaccatgtccagctaatttttgtatttttaatagagatggggttttgccatattagccaggctggttttgaac
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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