Basic Information
VIS ID
TVIS10005842
Fusion event
HBV-LINC02334 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1460
Orient
-
Integrated sequence
ACACCTCCTTCCCATGGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCC| |GTCTCGGGGCCGTTTGGGGCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCT
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
38591685/38017548 (Hg38)
End
38591685/38017548 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC02334
Nearest miRNA
hsa-mir-2276/Upstream/13855044; hsa-mir-1267/Downstream/1646486;
Nearest TSS
ENST00000623511/Upstream/82983; ENST00000464423/Downstream/43900;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/147457, chr13-CpG: 32/Downstream/332272
Upstream sequence
acattttttatatacctgttggccatttgtatgtcttcttttaagaaatgcctgttcatgttctttacccatttctgatgagataacttcttttttctgt
Downstream sequence
tgagttgttgggtccctttttattctgaatattagtcctttgttggatgaatagtttgcaaatattttctcccattcaacaggttgtctctccactctgt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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