Basic Information
VIS ID
TVIS10005855
Fusion event
HBV-chr6 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1833
Orient
-
Integrated sequence
GAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTG| |CCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCT
Host Sequence
Chromosome
chr6
Cytoband
p23
Reference genome
GRCh37/hg19
Start
14465273/14465042 (Hg38)
End
14465273/14465042 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6A
Target gene
LOC101928331 ; LOC101928354
Nearest miRNA
hsa-mir-3691/Upstream/4025248; hsa-mir-10398/Downstream/1676514;
Nearest TSS
ENST00000381078/Upstream/70716; ENST00000474854/Downstream/134648;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/253529, chr6-CpG: 113/Downstream/779604
Upstream sequence
aaatttcctctaattatattatagatttagaaaatagttaacctctaaatctggtatacttttactgttaggccatagattaaaaaaacaagctatacca
Downstream sequence
aaaacaggcaactttagcatattgattattttgagctgaatgaacagcagctgtaggaaaggctctctgatctctccctttctacccaaaagctggcaca
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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