Basic Information
VIS ID
TVIS10005858
Fusion event
HBV-RAD51B integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1726
Orient
-
Integrated sequence
CCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAA| |GGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
68412305/67945588 (Hg38)
End
68412305/67945588 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA14C
Target gene
RAD51B
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-30b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-569 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6871-5p ; hsa-mir-4496 ; hsa-mir-4506
Nearest miRNA
hsa-mir-208a/Upstream/503658; hsa-mir-1185-1/Downstream/4571232;
Nearest TSS
ENST00000550708/Upstream/37283; ENST00000554575/Downstream/54691;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/270423, chr14-CpG: 40/Downstream/682710
Upstream sequence
ttgtttgtttgttttttgtgacgaagtgttgctttgtcgcccagactggagtgcagtggcgcaatctctcctcccgggttcaagcgattctcgtgcctca
Downstream sequence
gcctcccgagtagctgggattacaggcacacgccaccacgcccagctaatttttgtatttttagtagagatggggtttcgtcatgttggccaggctggtt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate