Basic Information
VIS ID
TVIS10005862
Fusion event
HBV-TBX5-AS1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1630
Orient
-
Integrated sequence
TCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCA| |CCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGAC
Host Sequence
Chromosome
chr12
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
114848097/114410292 (Hg38)
End
114848097/114410292 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
TBX5-AS1
Nearest miRNA
hsa-let-7i/Upstream/1118684; hsa-mir-1178/Downstream/1738268;
Nearest TSS
ENST00000382841/Upstream/1538; ENST00000547819/Downstream/211469;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/447, chr12-CpG: 39/Downstream/3860
Upstream sequence
AAGAATTATAACAATAGAAATGATGACAAAACTAAACTTTGACCAATTCAATTTGCAAAAGAAAGGGTTGGTCTGAGGGTGAGACATTCCCTGGTTTCTC
Downstream sequence
AAGGGGGTCACTTTCCCTCTCACCGAGTTAAATCTGGCTCTGTTATATTTTTTCCAGGAACACAGTATGTCTCTTCCCAATGTTTTATTCGGTTTCTGGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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